Endocrine Abstracts

Background and aims: The aim of this study was to assess the effect of docosahexaenoic (DHA) and eicosapentaenoic acid (EPA) on the heart rate variability (HRV), dynamics of such biochemical parameters in patients (pts) with Type 2 DM and cardiovascular aunonomic neuropathy (CAN).Materials and methods: Forty-nine pts with CAN (54±5 years) were allocated in two groups. Pts of group A (n=17) were receiving capsules of fish oil every day (‘...

Background and aims: The aim of this study was to assess the effects of simvastatin (SIM), eicosapentaenoic (EPA), docosahexaenoic acid (DHA) on dynamics of such biochemical parameters in type 2 diabetic patients with cardiomyopathy (DCMP).Materials and methods: Twenty-five patients with DM and DCMP received SIM 20 mg tid (group A); B (n=37) – capsules of fish oil (‘Epadol’: 2.0 g EPA, 2.0 g DHA and 0.1% α-tocopherol acetate), ...

Case history: We report the case of a previously healthy 69-year-old female who was referred to our centre after she presented with rapidly progressive weight-gain, hyperglycaemia, hypokalaemia and hypertension. She had no symptoms suggestive of carcinoid syndrome. On assessment, she had pathognomonic features of Cushing’s syndrome: central weight gain (peripheral wasting) proximal myopathy, leg oedema, skin thinning, bruising and facial puffiness; this appearance being m...

Background: There is clear evidence that achieving optimal glycaemic control in type 1diabetes reduces the complications of diabetes. Increased technology use is associated with lower HbA1c. NICE target HbA1c is 48 mmol/mmol.Objective: Are there differences in HbA1c between patients with Type 1 diabetes using continuous glucose monitoring sensor (CGM) or hybrid closed loops in real world setting in paediatric patients at...

Introduction: The issue of the impact of disturbances of functional status of gonads in men on the development of type 2 diabetes mellitus (T2DM) has been studied for a long time. However, the results obtained appear to be ambiguous. A number of studies conclude that blood levels of testosterone (T) in men with DM are within the normal range of fluctuations and do not play a pathogenetic role. At the same time, recent epidemiological studies demonstrate a high prevalence of lo...

Assess the morphology of focal lesions of the adrenal glands after adrenalectomy, compare the results with the nature of the course of hypertension, the level of blood pressure, age, sex of patients.Materials and methods: Forty-four medical maps of patients operated on for focal formations of the adrenal glands were analyzed. The clinical symptoms, the hormonal activity of adrenal gland tumors - the level of cortisol, aldosterone, potassium, sodium, reni...

Background and aims: The metabolic syndrome (MS) – pathology, that is in the center of the attention of endocrinologists, cardiologists and therapeutics, is frequently diagnosed with the development of vascular complications, or of diabetes mellitus type 2 (DMT2).The aim of the present study is to investigate the occurrence of MS, according to IDF (2005) and DMT2 according to criteria WHO (1999) under the conditions of the primary component of publi...

Introduction: NETs are regarded as rare endocrine malignancies, which often present late. The COVID-19 pandemic may have affected this and patient care. The impact will have been felt in health service delivery and patient experiences. To understand NET patient perspectives and optimise care, we conducted a survey to review patient perception of: telemedicine-based care, delays to imaging, treatment, and the impact of COVID-19.Method: 70 NET patients tre...

Introduction: Polycystic Ovary syndrome (PCOS) is a metabolic disorder associated with increased cardiovascular disease risk. Exercise is an effective treatment strategy to manage symptoms and reduce long-term health risk. High-intensity interval training (HIIT) has been suggested as a more efficient exercise mode in PCOS; however, it is not clear whether HIIT is superior to moderate intensity steady state exercise (MISS).Methods: We synthesized availabl...

Case history: Idiopathic Infantile Hypercalcaemia (IIH) classically presents in the first year of life, usually resolves by 1 year of age and is due to mutations in 1,25-dihydroxyvitamin D2 24-hydroxylase (CYP24A1) or, rarely, sodium-phosphate cotransporter-2A (SLC34A1). We report a case of IIH in a Caucasian female, who was born to non-consanguineous parents, with hypercalcaemia, hypercalciuria and associated complications persisting into adulthoo...